Journal: Naunyn-Schmiedeberg's Archives of Pharmacology

Article Title: A population pharmacokinetic model of remdesivir and its major metabolites based on published mean values from healthy subjects

doi: 10.1007/s00210-022-02292-6

Figure Lengend Snippet: Simulated plasma concentration‐vs.‐time profiles of remdesivir, GS‐704277, and GS‐441524 following a simulated 30-min intravenous infusion of 200 mg of remdesivir on day 1, with 100 mg, 30-min intravenous infusion for the following 4 days. The bottom part of the remdesivir panel shows the fraction of censored observation numbers to the total observations at a given time. There were no censored observations for the metabolites. Dotted lines reflect standard deviation values

Article Snippet: Fig. 2 Observed mean concentrations (black dots) and model predictions (black line) of each given dose, following single 2-h intravenous infusion of either 3 mg, 10 mg, 30 mg, 75 mg, 150 mg, or 225 mg of remdesivir Fig. 3 Goodness-of-fit plots describing remdesivir model-predicted plasma concentration value agreement with the observed values Population parameter estimates for the mean of the published plasma concentration‐vs.‐time profiles of remdesivir, GS‐704277, and GS‐441524 following remdesivir 2-h single-dose intravenous administration in healthy volunteers are described in detail in Table .

Techniques: Concentration Assay, Standard Deviation

Journal: CPT: Pharmacometrics & Systems Pharmacology

Article Title: Does the choice of applied physiologically‐based pharmacokinetics platform matter? A case study on simvastatin disposition and drug–drug interaction

doi: 10.1002/psp4.12837

Figure Lengend Snippet: Modeling strategy of simvastatin lactone (SVL) and acid (SVA) in the selected platforms. ADME, absorption, distribution, metabolism, and excretion; DDI, drug–drug interaction; DGI, drug–gene interaction; J max , unbound maximum concentration; PBPK, physiologically‐based pharmacokinetic; PK, pharmacokinetic; SVA, simvastatin acid; SVL, simvastatin lactone; V max , maximal rate of metabolism.

Article Snippet: The f 1 value for SVL and SVA plasma concentration–time profiles across doses was 44 and 78% in Simcyp compared to 38 and 37% in PK‐Sim.

Techniques: Concentration Assay

Journal: CPT: Pharmacometrics & Systems Pharmacology

Article Title: Does the choice of applied physiologically‐based pharmacokinetics platform matter? A case study on simvastatin disposition and drug–drug interaction

doi: 10.1002/psp4.12837

Figure Lengend Snippet: Input parameter for SVL and SVA models

Article Snippet: The f 1 value for SVL and SVA plasma concentration–time profiles across doses was 44 and 78% in Simcyp compared to 38 and 37% in PK‐Sim.

Techniques: Molecular Weight, In Vitro, Permeability, Formulation, Dissolution, Solubility, Clinical Proteomics